Cellular Phenotype Plasticity in Cancer Dormancy and Metastasis

Cellular Plasticity in Prostate Cancer Bone Metastasis

Purpose. Experimental data suggest that tumour cells can reversibly transition between epithelial and mesenchymal states (EMT and MET), a phenomenon known as cellular plasticity. The aim of this review was to appraise the clinical evidence for the role of cellular plasticity in prostate cancer (PC) bone metastasis. Methods. An electronic search was performed using PubMed for studies that have e...

Cancer stem cells, tumor dormancy, and metastasis

Tumor cells can persist undetectably for an extended period of time in primary tumors and in disseminated cancer cells. Very little is known about why and how these tumors persist for extended periods of time and then evolve to malignancy. The discovery of cancer stem cells (CSCs) in human tumors challenges our current understanding of tumor recurrence, drug resistance, and metastasis, and open...

Disseminated tumor cells and dormancy in prostate cancer metastasis.

It has been reported that disseminated tumor cells (DTCs) can be found in the majority of prostate cancer (PCa) patients, even at the time of primary treatment with no clinical evidence of metastatic disease. This suggests that these cells escaped the primary tumor early in the disease and exist in a dormant state in distant organs until they develop in some patients as overt metastases. Unders...

Editorial: Cellular and Phenotypic Plasticity in Cancer

1 Oncogenic Signalling and Growth Control Program and Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia, 2 The Sir Peter MacCallum Department of Oncology, The University of Melbourne, East Melbourne, VIC, Australia, 3 Cancer Immunobiology, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia, 4 School of Cancer Medicine, La Trobe Univ...

Epithelial plasticity in cancer: beyond metastasis